Dog Liver Enzymes

"Dog liver enzymes are measured to determine if liver disease is present. Elevated levels require treatment."

Dog Liver Enzymes

Alanine Aminotransferase (ALT): ALT is a liver specific enzyme, meaning it is not found elsewhere in the body. Increases are not considered abnormal unless they are two to three times above normal, and even then, they can be caused by many things besides liver disease. For instance, inflammatory gastrointestinal disease, cardiac failure, and the abnormal breakdown of red blood cells (hemolytic anemia) can all cause elevated ALT levels, as high as four to five times normal levels.

An increase in ALT along with other liver enzymes is an indication of liver disease. Cell damage will cause elevations of ALT due to leakage. The elevation of the enzyme correlates with the number of cells damaged. Decreasing levels of ALT may indicate recovery or may indicate a falling number of functional liver cells.

Aspartate Aminotransferase (AST): AST is an enzyme found in the liver, heart, kidneys, skeletal muscle, and brain. The half-life of AST in the blood stream is much shorter than that of ALT, meaning that levels in the blood decrease much faster once liver function is restored.

Alkaline Phosphatase (ALP): This enzyme is present in many tissues, so it is not very specific in liver disease, but it appears very early in the progress of liver disease, so your vet will look for it anyway. The levels of ALP are often elevated in dogs who are on anti-convulsive medications. Levels of ALP also tend to be high in young, growing dogs such as puppies.

Gamma Glutamyltransferase (GGT): While this enzyme is found in the liver, its highest concentration is found in the kidneys and pancreas. Large elevations of GGT are associated with pancreatitis and bile duct obstruction.

Sources

Diagnosing Liver Disease in Dogs: What Do the Tests Really Mean?
Maddison, Jill

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