Cushings Disease Medications

by Ruth German
(West Lafayette, Ind. USA)

My dog has symptoms of Cushings disease. My vet informed me that after they do the acth stimulation test and if it is positive there is a new medication out that does not cure the disease, but alleviates the symptoms. This information came from Purdue veterinary school. Can you tell me the name of he medication.Also have you had any information on this and results.

Editor Comment - Available Cushing's Disease Medications

Hi Rush,

Yes, there is a medication called Trilostane that is commonly used to treat Cushing's disease in dogs. Trilostane is a drug that works by inhibiting the production of cortisol, one of the hormones that is overproduced in Cushing's disease. By reducing cortisol production, Trilostane helps alleviate the symptoms of the disease, including excessive thirst and urination, increased appetite, and lethargy.

Vetoryl (trilostane) is the only drug approved by the FDA to treat both pituitary- and adrenal-dependent Cushing’s in dogs. This prescription drug works by stopping the production of cortisol in the adrenal glands1 Anipryl (selegiline) is FDA-approved to treat uncomplicated, pituitary-dependent Cushing’s in dogs2 Lysodren (mitotane) is often used to treat dogs with Cushing’s2 However, it is important to note that Lysodren is a human chemotherapy drug and is not FDA-approved for use in dogs1

Trilostane is currently the most commonly used.

As you noted, while Trilostane can help alleviate the symptoms of Cushing's disease, it does not cure the disease. Cushing's disease is a chronic condition that will require ongoing management and monitoring. Your vet can provide more information about the potential benefits and risks of Trilostane and other treatment options, as well as what to expect in terms of results and prognosis for your dog.

All the best to you and your dog.

Dog Health Guide

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