Hello, I have a 9 year old Lhasa Apso who has been on Phenobarbital and Potassium Bromide for the past 4 1/2 years.
We did a blood test in January of this year and his enzymes were 430. My vet suggested we give him Denamarin - a liver supplement. We did a follow up blood test in April and the liver enzymes are now 795.
Of course I am very worried. He takes 45MG of Phenobarbital 2x a day and 30MG once a a day plus potassium bromide 300MG 2x per day.
Thank God he has not had seizures for the past 6 months which is such a blessing. He would have them 1x a month or every couple of weeks.
Now I don't know what to do. My vet told me to decrease the Phenobarbital.
I don't know. Should I change his food?
Any Advice? Need Help!
Veterinarian Suggestion Regarding Elevated Liver Enzymes in Epileptic Dog
The medications that your dog is on can cause elevations in his liver enzymes. I’m not sure exactly which laboratory value you are reporting on, but if it is alkaline phosphatase (ALP), I wouldn’t be too worried about numbers in the 430 to 795 range for a dog on phenobarbital.
It sounds like your veterinarian is doing a good job. If your dog were my patient I would also have put him on a liver protectant like Denamarin, recommended rechecks of his blood work every few months, and be trying to find the lowest effective dose of his medications.
If your dog’s lab results just sort of bounce around in the 400 to 800 range, it’s probably nothing to worry about. If they continue to climb however, some additional testing to rule out other causes of increased liver enzymes (e.g., Cushing’s disease) wouldn’t hurt.
Jennifer Coates, DVM
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